Recent advances on blinatumomab for acute lymphoblastic leukemia

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Recent Advances in Acute Lymphoblastic Leukemia

Epidemiology From data collected by the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute, it is estimated that there were 5330 cases of newly diagnosed ALL (3150 in males and 2180 in females) in 2010 in the United States, approximately 60% of which were diagnosed in patients younger than 20 years of age.[1] Hence, while the total number of cases of leu...

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Recent Advances in Acute Lymphoblastic Leukemia

Epidemiology From data collected by the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute, it is estimated that there were 5330 cases of newly diagnosed ALL (3150 in males and 2180 in females) in 2010 in the United States, approximately 60% of which were diagnosed in patients younger than 20 years of age.[1] Hence, while the total number of cases of leu...

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Advancements in Therapy for Acute Lymphoblastic Leukemia: Blinatumomab

© 2016 Harborside Press® Acute lymphoblastic leukemia (ALL) is a rare form of leukemia, with an estimated 6,250 new cases diagnosed in the United States in 2015 and approximately 1,450 deaths (American Cancer Society, 2015). With current available induction therapies, complete remission (CR) rates in adults are approximately 75% to 90% (Faderl et al., 2010; Bassan & Hoelzer, 2011). After induct...

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Recent advances in the management of pediatric acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is the most common malignancy in childhood. Despite enormous improvement of prognosis during the last half century, ALL remains a major cause of childhood cancer-related mortality. During the past decade, whole genomic methods have enhanced our knowledge of disease biology. Stratification of therapy according to early treatment response measured by minimal res...

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Treatment of Pediatric Acute Lymphoblastic Leukemia and Recent Advances

Pediatric acute lymphoblastic leukemia (ALL) is the most prevalent cancer in children. Today in developed countries around 80% of children with ALL can achieve 10 year survival. This great improvement in treatment outcomes for pediatric ALL is due to several important advances which have taken place since the 1960s, including intensive induction/consolidation chemotherapy regimens, risk-adapted...

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ژورنال

عنوان ژورنال: Experimental Hematology & Oncology

سال: 2019

ISSN: 2162-3619

DOI: 10.1186/s40164-019-0152-y